The intestine is critical to oxalate homeostasis
The intestine is responsible for dietary oxalate absorption and gastrointestinal oxalate secretion/excretion, offering an important pathway for oxalate removal in addition to the kidneys
Oxalobacter formigenes
Oxalobacter formigenes (Of) is an anaerobic microbe that lives predominantly in the large intestines. It consumes oxalate as its sole food source, and importantly, interacts with the colonic epithelium to induce colonic oxalate secretion via previously unidentified factors (depicted as blue spheres below).










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